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David L. Castaldi Independent Consultant Geoffrey F. Cox, Ph.D. Chairman & CEO GTC Biotherapeutics, Inc. George W. Ebright President & COO retired ; SmithKline Beecham Corporation Richard A. Harvey, Jr. President Stonebridge Associates, LLC Linda Jenckes President Linda Jenckes & Associates Thomas H. McLain Chairman, CEO & President Nabi Biopharmaceuticals Stephen G. Sudovar President & CEO retired ; EluSys Therapeutics, Inc.
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In June 2005. We out-licensed the anticancer agent HMN214 to IVAX Corporation of the U.S. and concluded a partnership agreement with Optimer Pharmaceuticals, Inc. of the U.S. on the quinolone antibacterial agent prulifloxacin. As for Trisenox Injection, we have agreed to transfer its South Korean rights to Jeil-Kirin Pharmaceutical Inc. Moreover, in order to expand our R&D pipeline, we concluded a co-development agreement with Hisamitsu Pharmaceutical Co., Ltd. for HFT-290, a tape for palliative care of cancer pain, and have begun jointly developing this compound in Phase III. Additional clinical trial on Urespan for overactive bladder is progressing smoothly, and the centrally acting analgesic NS-315 is under preparation for NDA. As to other compounds, TRK-091 is in Phase II trial, NS-126 is in Phase III trial for allergic rhinitis and in PhaseII for bronchial asthma, and NS-9 is in Phase I trial in the US for liver cancer. We have completed Phase I trial on NS-101 DepoCyt ; for neoplastic meningitis and NS-11 acamprosate ; for alcohol dependence. We have also concluded a joint development and sales agreement with Janssen Pharmaceutical K.K. for NS-315 in Japan and piroxicam.

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